DERIVATIZED GUAR GUMS BASED HYDROGEL FILM AS CARRIER FOR PIROXICAM

Abstract

A recent study has been performed on making hydrogel films with hydroxypropyl guar gum and carboxymethyl guar gum crosslinked with citric acid. The crosslinking of HyPGG, CaMGG, and CTA into a film-like structure was achieved through a crosslinked network structure. Due to their biocompatibility and biodegradability, both HyPGG and CaMGG have the potential to be used as hydrogel films for drug delivery systems. The research revealed that, the drug carrier CaMGG-based hydrogel, syntheses have exhibited noticeable viscoelastic properties, surface morphology, and thermal behaviour. On the other hand, HyPGG has been applied in initial studies creating network hydrogel platforms designed for drug delivery that could present a combination of local drug delivery properties in combination with biological compatibility. The customized drug release features of both derivatives make them suitable for targeted drug delivery applications in pharmaceutical and biomedical fields. The use of crosslinker as citric acid has been discussed in various compositions of citric acid crosslinked hydrogel films in several research studies. Previous inquiries have suggested that the citric acid could be used as crosslinker and were found to improve the properties of hydrogel that produced from natural polymer. The use of citric acid in hydrogels enhances water resistant properties, and had better mechanical and physical properties. Due to its biocompatibility, citric acid can form ester bonds and it is environmentally safe, which has played a significant importance in making the films of this hydrogel could be applied on tissue engineering and wound treatment. Thus, the investigation of the synthesized hydrogel film was carried out using different characterization methods. Thermogravimetric Analysis (TGA) was used to study the thermal decomposition of the hydrogel film. The structural properties were investigated by ATR-FTIR (attenuated total reflection -Fourier Transform Infrared Spectroscopy) and XRD (X-ray Diffraction). Field Emission Scanning Electron Microscope (FE-SEM) has been performed onto hydrogel film for morphological examination. The viscoelastic behaviour of hydrogel film was evaluated by rheological analysis. The prepared hydrogel films incorporated with Piroxicam was as a vehicle vi for advanced drug delivery system. The hydrogel film’s in vitro drug release was studied in PBS 7.4. The HyPGG-co-CaMGG-cl-CTA hydrogel film followed Korsmeyer-Peppas model and followed Fickian diffusion in pH 7.4. This shows potential of the hydrogel film to act as a carrier for innovative drug delivery systems.