SYNTHESIS OF BIOLOGICALLY IMPORTANT HETEROCYCLES FROM ALKYNES AND FUNCTIONAL GROUP TRANSFORMATIONS

Abstract

The thesis describes transition-metal-free synthesis of novel nitroacridinamines, nitrobenzo[c]acridinamines, nitroquinolinamines and late-stage modification of some biologically relevant molecules and natural products. Another base-mediated protocol has been established for the N-acetylation of anilines/amines at room temperature. Reaction utilizes acetonitrile as a solvent as well as a surrogate of the acetyl group. Apart from acetonitrile, trifluoroacetonitrile could also be utilized in the reaction. The thesis also describes Potassium tert-butoxide mediated a direct one-pot synthesis of diversely substituted nitriles from aldehydes via the sequential addition of hydroxylamine and benzoyl chloride. Broad substrate scope, easy operation, quick reactions, tolerance of different functional groups, reactions are the important features of all developed methodology. Various techniques such as 1H NMR, 13C NMR, 19F NMR and mass spectrometry have been used for characterization of those organic compounds.