IN SILICO APPROACH, TO STUDY THE PHYTOCHEMICALS FROM NERIUM OLEANDER AS POTENTIAL MEDICAMENT FOR CARDIAC ARRHYTMIA

Abstract

Cardiac arrhythmias pose a significant burden on global health, contributing to morbidity and mortality worldwide. Ion channels play a crucial role in cardiac physiology, and dysfunction in these channels is implicated in the pathogenesis of various arrhythmia syndromes. Conventional drugs, which are often prescribed to treat cardiac arrhythmias, are costly and have negative effects. Therefore, a more reliable, affordable, and powerful alternative is needed. Medicinal herbs are, thus, the most important kind of treatment for cardiac arrhythmia. This dissertation explores the computational discovery of phytochemical for targeting protein which in turn target ion channels implicated in cardiac arrhythmias, focusing on molecular docking simulations and understanding therapeutic approach by using herbal plant. Key findings include the identification of potential phytochemical with the ability to modulate ion channel function and restore normal cardiac rhythm. Insights into the mechanism of action of cardiac glycoside reveal their ability to regulate cardiac rhythm by primarily increasing vagal tone, which slows AV node conduction and reduces the ventricular rate. The implications for drug discovery and therapeutic development are discussed, highlighting the potential of phytochemical as a precision medicine approach for personalized treatment strategies tailored to the underlying molecular mechanisms of arrhythmia subtypes. Recommendations for future research include experimental validation of lead compounds, structural biology studies to elucidate ligand-protein interactions, clinical translation of computational predictions, and the investigation of personalized medicine approaches based on patient-specific genetic mutations. By addressing these recommendations, the field can further advance our understanding of cardiac arrhythmias and facilitate the development of innovative therapeutic interventions for improving patient care and outcomes.