IN SILICO APPROACH FOR THE TREATMENT OF DIABETES TYPE 2 BY TARGETING PTP 1 B WITH PLANT DERIVED NATURAL COMPOUNDS

Abstract

Type 2 diabetes is a persistent medical condition characterized by heightened blood sugar levels, also referred to as type 2 diabetes mellitus or adult-onset diabetes. This form of diabetes develops when cells resist the usual effects of insulin in facilitating the movement of glucose from the bloodstream into the cells, a state known as insulin resistance. PTP1B has been associated with inhibiting insulin and leptin functionality both experimentally and clinically. In a preclinical study, substances that target PTP1B in insulin-sensitive tissues demonstrated improvements in insulin function and glucose tolerance. This investigation sought to isolate natural compounds from various plants that displayed potential effects in managing type 2 diabetes. Through the use of in silico methods, the study identified a potent inhibitor of PTP1B with the potential to offer therapeutic benefits for individuals with type 2 diabetes.