EXPLORING THE POTANTIAL OF Ziziphus jujuba IN ARTERIOSCLEROSIS: A NETWORK PHARMACOLOGY APPROACH

Abstract

The use of traditional herbal medicines in the medical management of various acute and chronic conditions in the modern world has been enhanced through the integration of the two. The antitherapeutic property of Ziziphus jujuba plant, a plant commonly referred to as jujube, is examined in relation to arteriosclerosis, a life-threatening cardiovascular disease. Ziziphus jujuba, also known as jujube fruit or ber in India, has long been used for traditional medicine, with the bark of the root used to treat coughs, biliousness, and headaches, and the bark of the stem used to treat boils, dysentery, and diarrhea. The plant exhibits various pharmacological properties as mentioned, which include anti inflammatory, anti-microbial, anti-cancerous, cardioprotective, nephroprotective, anti oxidant, gastrointestinal protective property and others. Therefore, we analyzed its bioactive chemicals and protein-target interactions with arteriosclerosis proteins consistently identified by network pharmacology and molecular docking. As by using network pharmacology we can understand complex disease, finding hub genes that are more closely related to the disease and for netter molecular docking results. The outcomes identified several highly effective phytochemicals in ZJ that bind to relevant target genes related to the development of arteriosclerosis. Molecular docking further proved drugs attachment probability to critical proteins including TNF and IL-6. Thus, the results presented in the work show that Ziziphus jujuba has high antigeneotic activity and possesses significant anti-arteriosclerotic effects which can serve as the basis for its use in the treatment of cardiological diseases.