TARGETING TREM2: IN-SILICO STUDY OF INTERACTIONS WITH GUT MICROBIOTA BASED SUPPLEMENTS FOR ALZHEIMER’S DISEASE

Abstract

Aim: To study the interaction between the receptor TREM2 and the supplements of bacterial strain A. muciniphila to target neuroinflammation in AD. Methodology: Material and methodology used for whole study includes the variant determination, docking analysis of the test ligands, protein-protein interaction analysis or String analysis and ADME analysis to validate the results and finding. Result: Herein we found that out of the considered supplements of the microbe of interest A. muciniphila mannitol, maltitol metformin, maltitol showed the maximum efficacy or binding affinity towards the receptor TREM2 but after conducting the ADME analysis we found that maltitol does not cross the Blood Brain Barrier (BBB), Lipophilicity in the optimum range, it is highly polar and flexible hence not suitable for oral administration, water soluble Pharmacokinetic analysis shows that is has lower absorption for GI and does not cross the BBB, also the ligand of interest does not respond to the inhibitors and it is not skin permeable. Conclusion: The study concludes that the bacterial strain and its prebiotic supplements are not suitable for targeting neuroinflammation as it does not satisfy the required criteria for docking as well as drug development.