IN SILICO ANALYSIS OF MICROBIAL ENZYMES FOR DEGRADATION OF BISPHENOL A (BPA) AND ITS DERIVATIVES

Abstract

Current industrial and human activities, whereby EDCs-like compounds such as BPA have become more prevalent in the environment (an environmental contaminant) over decades. This synthetic chemical of polycarbonate and epoxy resins used in plastics disrupts endocrine functions with major health, and environmental risks known as BPA. The present study, with the most comprehensive analyses by looking at multiple health outcomes of BPA exposure should warn us about its serious effects on health leading to various endocrine diseases such as perturbation in thyroid function, metabolic disturbances, reproductive health issues, and hormone-dependent cancers. In practice, replacing BPA by analogs such as Bisphenol B, S, F, Z, and AF does not necessarily solve the problem because these substitutes have an equivalent or greater toxicity than BPA raising new health problems such as autism spectrum disorder (ASD), breast cancer, diabetes and polycystic ovary syndrome. This study reveals how current methods for degradation of this nature are ineffective, and often lead to pollution of soil and water. Microbial degradation is an assuring method to degrade these compounds. This study utilizes molecular docking to explore the interaction between BPA and microbial enzymes. This study aims to pick out effectual bioremediation by grasping the binding mechanism of three enzymes with BPA. This study contributes to developing a safe ecosystem by understanding the binding mechanism of BPA, mitigating the risk to health concentrating on the necessity for safer options, and spreading awareness to the public.