FABRICATION AND ASSESSMENT OF ACACIA GUM-BASED HYDROGEL FOR DELIVERY OF CIPROFLOXACIN

Abstract

In the current research, various hydrogel formulation comprised of acacia gum (AG), polyacrylamide (PAM), and carboxymethyl tamarind kernel gum (CMTKG) were fabricated and ciprofloxacin loading were carried out. The evaluation of different crosslinker and initiator amount on the swelling ratio of the synthesized hydrogel was assessed. Powder X-ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), and Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) techniques were used to characterize the hydrogel. The hydrogel swelling and in vitro drug release were evaluated using buffer of pH 1.2 and 7.4. The results showed that, in comparison to acidic pH, an alkaline pH produced better results for the swelling and in vitro drug release. The ciprofloxacin-loaded AG/PAM/CMTKG hydrogel drug release kinetics revealed non-fickian mechanism at pH 7.4 and fickian diffusion at pH 1.2, respectively, according to the Korsmeyer– Peppas model. The pH-dependent behavior of ciprofloxacin-loaded AG/PAM/CMTKG hydrogel displayed its possible consequences for site-specific ciprofloxacin release.