ROLE OF CENTELLA ASIATICA PLANT’S EXTRACT IN THE PARKINSONISM: A MOLECULAR DOCKING APPROACH

Abstract

Parkinson disease is one of the highly prominent neurodegenerative disorders later than Alzheimer’s disease, signified by the ongoing death of dopaminergic neurons in the central brain portion named substantia nigra pars compacta. Pathological parkinsonism is supported by the aberrant accumulation of α-synuclein, which the vital hallmark of Parkinson disease. Several other hall mark of Parkinson disease is chronic activation of microglia or astrocytes cell, oxidative stress, mitochondrial dysfunction, cellular cytotoxicity and brain inflammation. Parkinson is defined by motor and non motor symptoms. Bradykinesia, resting and rhythmic tremor, rigidity and abnormal body reflexes are the motor symptoms and on the other hand non motor symptoms are pain in several areas, sleeping disorder and mental issue in some cases. Oxidative stress is one the key marker in Parkinson nowadays and generation of ROS (Reactive oxygen species) is the main cause of oxidative stress in PD. Several therapeutic techniques and medication are effective on symptoms but not all the permanent effective. Centella asiatica popular herbs, used in several disorder like skin issues, cancer and wound healing. With their antioxidants properties recently C. asiatica gained much popularity and may effective in the oxidative stress and other parkinsonism supports.