EXPLORING THE THERAPEUTIC POTENTIAL OF PHYTOCHEMICALS: MOLECULAR DOCKING STUDIES IN BREAST CANCER

Abstract

The term "cancer" refers to a category of disorders in which some body cells begin to grow unnaturally and uncontrollably, killing millions of people globally. Metastasis is the term for the process by which tumour cells spread or infiltrate into other body parts or tissue. Breast cancer is one type of cancer that can appear in the breast tissue. Breast cancer can also affect men, although it is much less prevalent and is more often found in women. One of the most prevalent cancers in the world, breast cancer primarily affects women and very occasionally men. even though it is far less frequent. One of the most prevalent cancers in the world, breast cancer primarily affects females and occasionally males. Over the past few decades, a lot of research has been conducted to increase our understanding of the complexities of breast cancer and offer effective management strategies. This abstract provides a concise review of recent advances in the understanding and management of breast cancer, encompassing both diagnostic and therapeutic The diagnostic landscape for breast cancer has changed significantly, mostly as a result of the evolution of cutting-edge imaging equipment and biomarker based testing. Breast abnormalities can now be detected using tomosynthesis, MRI, and digital mammography, which also helps in the early detection of malignant tumours. The identification of novel biomarkers, including HER2/neu, hormone receptors (oestrogen and progesterone), and the proliferation marker Ki-67, has also enabled a more precise classification of breast cancer subtypes. This has facilitated the creation of individualised treatment plan The paradigm for treating breast cancer has undergone a significant change, shifting towards one that is interdisciplinary and personalised. This study makes use of a number of computational tools, including Autodock Vina, Pymol, Protein Drug Bank, and PILP. PILP (Protein-Interaction Ligand Profiler). The interactions between cyclin D and plant phytochemicals are examined by means of PILP and molecular docking of the protein and ligand. Studying the interactions between proteins and ligands helps with drug discovery. The goal of this research is to determine which plant phytochemicals are most successful at preventing human cancer.