FELODIPINE- CHEMISTRY AND MEDICINAL APPLICATIONS

Abstract

This thesis provides a comprehensive review of Felodipine, a dihydropyridine calcium channel blocker, focusing on its structure, chemical properties, synthesis, mechanism of action, drug interactions, and recent advancements. Felodipine has emerged as a significant therapeutic agent for the treatment of hypertension and other cardiovascular disorders. The introduction section emphasizes Felodipine's therapeutic significance as a potent antihypertensive agent and highlights its selectivity for vascular smooth muscle cells, reducing the risk of negative cardiac effects. The structure section delves into the unique chemical structure of Felodipine, featuring a dihydropyridine ring and various substituents. This structure provides a foundation for designing related compounds with improved pharmacological properties. The chemical properties of Felodipine, such as its physicochemical characteristics, solubility, and stability, are examined, consolidating the current understanding of its behaviour. The synthesis section explores the complex process involved in the production of Felodipine. Different synthesis methods and approaches are reviewed to identify the most efficient and viable techniques for synthesizing this compound. A detailed understanding of the synthesis pathways and underlying chemistry is crucial for optimizing production and exploring modifications. The mechanism of action section sheds light on how Felodipine exerts its pharmacological effects by selectively inhibiting calcium influx into smooth muscle cells, leading to vasodilation and blood pressure reduction. The drug interactions section highlights the potential interactions resulting from Felodipine's metabolism, particularly through the cytochrome P450 system, stressing the need for careful consideration when prescribing concurrent medications. Recent advancements in Felodipine research and its potential therapeutic applications beyond cardiovascular indications are explored, indicating the expanding scope of this compound. This thesis contributes to the knowledge and understanding of Felodipine's pharmacological potential, providing insights for further research, optimizing therapeutic outcomes, and inspiring the development of novel derivatives or formulations.