ANALYSIS OF GUT MICROBIOME DIVERSITY AND INVESTIGATING ITS ONCOLOGICAL IMPLICATIONS

Abstract

In recent years, the understanding of human well-being has undergone a transformative shift, attributing significant importance to the intricate interplay between the gut microbiome and human health. The vast community of microorganisms residing in the gastrointestinal (GI) tract has emerged as a critical regulator of immunological functions, capable of influencing various signal transduction pathways and immune responses. Particularly in the context of cancer, the gut microbiome is increasingly recognized as a pivotal player in the development and progression of this complex disease. Motivated by these advancements, our research project aims to construct a comprehensive and comparable risk evaluation database. This database encompasses diverse ethnic groups, their dietary habits, cancer incidence rates, and insights into the intricate connections between diet, gut microbiota composition, and cancer risk from relevant cohort studies. By integrating these multi-dimensional data sources, we strive to unravel the complex relationships between diet, gut microbiota, and cancer, shedding light on potential therapeutic targets for enhancing human well-being. The project will involve extensive data mining and analysis of available cohort studies, allowing us to assess the diversity of the gut microbiome across different populations and its potential implications in cancer. We employed methodologies to process and interpret metagenomic data, identifying prevalent microbial and HLA biomarkers associated with GI tract cancers. Moreover, by comparing the relative abundance of bacterial genera between cancer cases and non-cancer individuals within each population, we aim to discern potential associations and gain deeper insights into the role of gut microbiota in cancer development. It is crucial to emphasize that the creation of this risk evaluation database does not establish causation between the gut microbiome, diet, and cancer but rather provides a platform for comprehensive analysis and comparison. Focus on elucidating the underlying mechanisms and interactions between the gut microbiome, host immunity, and cancer development, will the way for potential therapeutic interventions and personalized strategies for cancer prevention and treatment.