SYNTHESIS AND CHARACTERIZATION OF NOVEL XANTHAN GUM-BASED pH-SENSITIVE HYDROGEL FOR METFORMIN HYDROCHLORIDE RELEASE

Abstract

In the current study, the synthesis of hydrogel based on carboxymethyl tamarind kernel gum (CMTKG), poly sodium acrylate (PSA), xanthan gum (XG), and its loading with Metformin hydrochloride (Metformin HCl) was successfully carried out and characterized using various techniques. Further, the optimization of hydrogel was done by varying the amount of CMTKG, MBA, or KPS, and their influence on the swelling ratio was examined. The fabricated hydrogels were characterized by Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR), Powder X-ray Diffraction (PXRD), and Scanning Electron Microscopy (SEM), whereas thermal stability was confirmed by Thermogravimetry Analysis (TGA). The hydrogels' swelling ratio and drug release studies were assessed in pH 1.2 and 7.4 buffer solutions and showed better results in alkaline pH. The drug release profile of Metformin-loaded CMTKG/PSA/XG hydrogel obeyed the Korsmeyer-Peppas model and follow non-fickian diffusion in pH 7.4 and fickian diffusion mechanism at pH 1.2. This pH-dependent behavior of the Metformin HCl- loaded CMTKG/PSA/XG hydrogel could be applicable for site-specific release of Metformin HCl.