IDENTIFYING TINOSPORA CORDIFOLIA BIOACTIVES WITH THE HIGHEST ANTI INFLAMMATORY THERAPEUTIC POTENTIAL TO DOWNREGULATE THE NF-KB PATHWAY

Abstract

Our study focuses on the ability of bioactives contained in Tinospora cordifolia (Giloy) to decrease inflammation caused by an auto-immune response in the human body. Alkaloids, Diterpenes, Sterols, Glycosides, Aliphatic Compounds, and Hydroxycinnamic Acids are among the medicinal bioactives found in Giloy. The ability of these medicinal bioactives to control NF-kB is being investigated. In the immune system, NF-kB is a dimeric transcription regulator found in the cytoplasm of all cell types. It is engaged in many metabolic activities and plays an important part in many biological processes, but its malfunction leads to auto-inflammatory disorders. As a result, our study looked into the possibility of bioactives in giloy aiding in NF-kB downregulation. The approach of finding possible drug candidates was based on molecular docking. The one with good ADME characteristics and binding affinity, as well as the existence of polar interaction, was discovered.