STUDY ON UTILIZATION OF AGRO-WASTE AS SOURCE FOR HEPARIN

Abstract

Heparin is a highly sulphated and most negatively charged natural biopolymer belonging to the glycosaminoglycan (GAG) family. This is about a 100-year-old anticoagulant drug. This is equally important for non-anticoagulant diseases also and is the reason for the recent burgeoning of interest in the molecule. Heparin has been isolated from both animal and non-animal sources; however, porcine mucosa remains the FDA-approved source for heparin. For the synthesis, chemical, chemoenzymatic, and biotechnological approaches have been studied. In recent times, the focus is more on synthesizing LMWH, ULMWH, and bioengineered heparins. A sustained and healthy society needs proper utilization of the waste material to deal with the increasing pollution rate. Several works are successfully done on this note, and till now, several strategies have been developed for the production of bio-chemicals from biological waste. In other words, value has been added to the waste materials. The biochemicals like starch, maltose, amylose, etc. have been isolated from the biological waste. These biomolecules may be used as a source of heparin synthesis to avoid the synthetic dependency of living organisms. Here in this work, I have explored the possibilities of biomolecules isolated from waste as source of heparin synthesis.