A STDY ON FLAVONOIDS TO AMELIORATE THE CAUSE OF VARIOUS NEURODEGENERATIVE DISEASES

Abstract

NEURO-DEGENERATIVE DISEASES ARE STILL INCURABLE AND THE CURRENT MEDICATIONS THET ARE AVAILABLE CAN JUST CONTROL THE SYMPTOMS OF THE DISEASES WITH A NUMBER OF HARMFUL SIDE EFFECTS. IN ORDER TO REDUCE THESE EFFECTS, NATURAL COMPOUNDS SUCH AS SECONDARY METABOLITES CAN BE THOUGHT OF AS A REPLACEMENT. ONE OF THE CATEGORIES OF THE SECONDARY METABOLITES IS THE FLAVONOIDS THAT ARE KNOWN TO POSSESS A NUMBER OF SIGNIFICANT HEALTH BENEFITS FOR THE HUMANS AND THEREBY CAN AS A REPLACEMENT FOR THE CONVENTIONAL DRUGS THAT ARE APPROVED FOR THE VARIOUS NDDs BECAUSE OF THEIR BETTER EFFECTIVENESS AND FEWER OR NO SIDE EFFECTS. THESE FLAVONOIDS CAN BE OBTAINED FORM VARIOUS NATURAL SOURCE SUCH AS THE PLANTAE KINGDOM. A PART OF THE PLANTAE KINGDOM IS HERBS AND SPICES, WICH ARE USED IN FOOD AND BEVERAGES SINCE TIME IMMEMORIAL TO ENHANCE THE COLOR, FLAVOR, AND AROMA. THESE HERBS AND SPICES ARE THE EASILY AVAILABLE THINGS IN A HOSEHOLD. FOR THIS, A DATABASE OF THE FLAVONOIDS THAT ARE THE PRESENT IN THE INDIAN HERBS AND SPICES WAS CREATED, AND THEY FORMED THE BASIS OF THIS STUDY. THE STUDY DEALS WITH THE SCREENING OF THE FLAVONOIDS BY PREDICTING THEIR ADME PREDICTIONS, TOXICITY, BIOACTIVITY, AND THEREBY DOCKING THE SCREENED FLAVONOIDS WITH THE DRUG TARGETS OF THE VARIOUS NDDs, IN ORDER TO LIIT THE UTILIZATION OF THE CONVENTIONAL DRUGS. BY THIS IN SILICO STDY, WE WOULD BE ABLE TO PREDICTS THE PHARMACOKINETIC PROPERTIES AND COMPARE THE BINDING AFFINITIES OF THE CONVENTIONAL DRUGS WITH THE SCREENED FLAVONOIDS.