DRUG REPURPOSING/REPOSITIONING

Abstract

This paper highlights the approaches, opportunities and challenges faced by the fairly new techniques of drug repurposing. The development of new drugs from older, rejected or already existing drugs by a cost effective and a time-efficient process involving various assays is discussed below. The paper aims to draw attention towards dissimilarities between traditional drug development and newer processes of drug repositioning & experimental and computational approaches. This project deals with the techniques involved, the shortcomings and the numerous drugs repurposed with the help of various assay and methodologies with examples. It also discusses the types of drugs that can be repurposed and the pros and cons. Drug repositioning may turn into a vital methodology for drug disclosure as far as time-and capital-competency contrasting with ordinary medication revelation and advancement

measure. Drugs can be re-purposed by various ways which include experimental and the in- silico based approach. Most approaches employed are according to the first stage of

identification of lead candidate since it needs more sophisticated and systematic approaches. There are various other methodologies that are employed in the drug repurposing/repositioning like phenotype screenings, targeting 3-D structures among others. Drug repurposing offers a great scope for many orphan diseases as well but great opportunities come with challenges.