ROLE OF METFORMIN IN INSULIN RESISTANCE IN PCOS

Abstract

Poly cystic ovarian syndrome (PCOS) is still being said to be one of the strangest hormonal & metabolic disorder common among among females of the child bearing age group. The various clinical manifestations of PCOS appears not only morphologically but also physiologically. Although psychological effects are also being seen apart from these, but they have been deliberately avoided in this review and the topic has been centralised keeping in demand of the topic where hormonal and metabolic issues have been addressed. Chronic consequences of PCOS also include T2DM and insulin resistance. Metformin, one of the widely used hypoglycemic drug, is also used nowadys in treating the metabolic issues found out in PCOS patients. This drug was also used not in addressing these manifestations but also in inducing ovulation along with combination of some other drugs which were also further helpful in treating the issue of anovulation, infertility and make greater chances of conception. This dissertation is basically a review of all the literature studies I have done in my whole journey. Also there was a variability of data in all these literature studies and therefore only the qualitative data that facilitated in designing my dissertation. Later in this review, it was confirmed that how the metformin usage was useful in regulating all the dysfunctioned consequences of PCOS like control of insulin sensitivity. Biochemical effects included reduced unbounded testosterone levels in blood and an augmented SHBG levels. However, data supporting the weight loss in PCOS still requires a lot of research. Further assessment for the long term effectiveness, who are the benefeciaries,and its optimal duration of usage.