MOLECULAR DOCKING STUDIES OF PHYTOCOMPOUNDS FROM “WITHANIA SOMNIFERA” AGAINST IL-6 AND JAK3 TARGETS IN RHEUMATOID ARTHRITIS

Abstract

Withania somnifera is the high valued plant known for its surprising therapeutic potentials. Withania somnifera is a significant shrub known for its versatility in ayurvedic system used for treatment of many disorders, from neurogenerative disorder to inflammatory illness.Rheumatoid arthritis (RA) is an autoimmune disease that is persistent in nature and with-long lasting effects, that is associated with joint pain, chronic inflammation, cartilage damage and bone erosion. Globally, 1-3 % of the population is afftected by it. The Rheumatoid arthritis is characterized by chronic inflammation, that is coordinated by Cytokine

signaling and Signaling Pathways. And as we know Withania somnifera has anti- inflammatory properties that could use against Rheumatoid arthritis. IL-6 and

JAK3 are connected with pathogenesis of rheumatoid arthritis (RA). Targeting these cytokines and signaling may open new approaches to treat Rheumatoid Arthritis. Docking studies concluded phyto constituents of Withania somnifera may have immense therapeutic potential against both anti-rheumatoid arthritis targets.