DOCKING OF PHYTOCHEMICALS OF MEDICINAL PLANT FICUS RELIGIOSA WITH HUMAN HISTAMINE H2 RECEPTOR

Abstract

Medicinal plants have been used as a source of medicine to treat health disorders and to prevent diseases including epidemics. Plants produces active compounds during secondary metabolism, and these active compounds are usually responsible for the biological properties of plants. Medicinal plants are used for various purposes including treatment of infectious diseases and allergy. The biological name of Peepal is Ficus religiosa. It belongs to the family of Moraceae. The tree has various therapeutic values as it is a source of several useful chemical compounds. Histamine has been recognized as a major mediator in allergic diseases plays a much wider and critical role as a pro-inflammatory mediator in allergic disease. This study is to focus on the range of phytochemicals present in F.religiosa and perform docking of these phytochemicals with the human Histamine H2. Docking was performed to access binding affinities between phytochemical and modeled receptor. The analysis suggested that lanosterol, α-amyrin acetate, Ergost-5-en-3beta-ol, germacrene, bergaptol, bergapten, gamma-cadinene form the most stable complex with human histamine H2 receptor. These compounds may be a suitable as therapeutic agent against inflammatory and allergic diseases.