METHCARD: A CARDIOVASCULAR DISEASES GENE METHYLATION DATABASE FOR HUMAN

Abstract

DNA methylation can be elucidated as the reversible addition of methyl (CH3) group to C5 position of cytosine to form 5-methylcytosine that symbolizes an important regulatory layer associated with gene expression and regulation. It needs to be precisely regulated as any alteration in DNA methylation pattern may lead to various diseases. Recent studies have provided evidence of relation between DNA methylation and cardiovascular disease. Thus to facilitate improved diagnosis and better treatment decisions, the objective of this study is to create an efficient, effective and accurate systems to enable the extraction of the detailed information related to methylation of genes involved in cardiovascular disease development by contributing resources from various databases namely Coronary Artery Disease Gene Database (CADgene), DisGeNET, Comparative Toxicogenomics Database (CTD), DiseaseMeth, Dragon Database for Methylated Genes and Diseases (DDMGD), Database of CpG islands and Analytical Tool (DBCAT) etc. and various published literatures.