METHSRD, SNIPSRD & INTERACTSRD : A COMPUTATIONAL DATABASE FOR GENES ASSOCIATED WITH DERMATOLOGIC DISORDERS

Abstract

The most prevalent and utmost visible organ of the body is skin. Epigenetic involves in regulation of cell growth & differentiation deprived of inducing various changes in the gene sequence. The major epigenetic mechanisms are DNA methylation. Latest studies specify that inconsistent DNA methylation is a most common piece of many human disorders, including heart diseases, skin diseases, cancer and others. The reversible addition of methyl groups at CpG dinucleotides are elucidated as DNA methylation. For various diseases to diagnose and for better treatment decisions, it is necessary to gather information that makes an association between methylated genes and diseases. As the data about the methylation, single-nucleotide polymorphism and PPI data of various genes related to dermatological disordersis scattered across a large number of electronic publications, several specialized databases, and other repositories, in the present work, we have developed a manually curated online database to enable the extraction of the detailed information related to methylation, single-nucleotide polymorphisms, and interaction of genes by contributing resources from published literature and available databases. To the best of our knowledge, this is the first online repository containing information related to genes methylated in dermatological disorders. We believe that the database will be useful to the biomedical community for identifying novel mechanisms associated with genodermatoses.