SYNTHESIS AND CHARACTERIZATION OF S-PEG FOR DELIVERY OF ARTHRITIS DRUG

Abstract

The Self assembled polymer based nanostructures have been the focus of research in the past decade because of their significant role in various biological system. In this study, a modified sulfasalazine was conjugated with a Polyethylene glycol 750 monomethylether to construct a multifunctional conjugate, sulfasalazine-PEG in millique into a miscelle type structure and to deliver the arthritis model drug sulfasalazine. The formation of nanostructure was confirmed by TEM and DLS analyses. The mean size of the sulfasalazine PEG was determined i.e. ~212.9 nm and having zeta potential of about -2.49 mV. In this nanocarriers which can be used to encapsulate hydrophobic drug ornidazole and sulfasalzine so there is hydrophobic and hydrophilic interaction between the drug and polymer and release profile of drug was studied at different pH 4.5 and 7. MTT assays showed the non-toxic behaviour of drug and polymer conjugate when performed at different concentration of these conjugate, drug and polymer. So all these results determine that these nanostructures synthesized are used as efficient vector for drug delivery application.