AN IN SILICO APPROACH TO INVESTIGATE THE THERAPEUTIC POTENTIAL OF AYURVEDIC DRUGS AGAINST ALLOPATHIC IN TREATMENT OF ALZHEIMER'S DISEASE (TYPE-3 DIABETES)

Abstract

Type-3 Diabetes is a term coined for Alzheimer’s disease that is supposed to progress from Type-2 Diabetes Mellitus in response to insulin resistance in brain. It has been reported that more than 5 million people in US are suffering from Alzheimer’s Disease and approximately 21 million have Type-2 Diabetes with a continuous increase in number of affected patients. The main symptoms of Alzheimer’s disease include cognitive decline, aggression, mood swings, depression, hallucinations, disoriented muscle movement and loss of appetite. Currently, a number of mechanisms have been proposed establishing the crosstalk between both the diseases, the crucial ones being insulin resistance, inflammation and altered insulin signaling. Since, no effective drugs are available in the market till date due to their side effects that slowly worsen the situation after short term of their use, therefore, we have proposed here an alternative treatment strategy using ayurvedic drugs in comparison with the potential drugs that have been or are being used in clinical trials. Herein, (i) we have identified the target hotspots that have the potential to prevent the progression of both Alzheimer’s Disease and Type-2 Diabetes, (ii) predicted the active site residues of the identified targets, (iii) screened the ayurvedic drugs for their drug likeliness and other essential physiochemical properties, (iv) comparatively analyzed the binding affinity and interacting residues of screened targets with ayurvedic drugs with Metformin as a control, (v) identified the putative ayurvedic drug that can be used for ameliorating the symptoms of Alzheimer’s Disease and Diabetes.