ARD INTERACT: CONSTRUCTION, VISUALIZATION AND ANALYSIS OF ARD NETWORKS

Abstract

Age-Related Disorders are the complex disorders associated with the process of ageing affecting the quality of life of our elderly population. Understanding the biology of ageing and age-related disorders has thus become one of the most important field of research in medicine and requires integration of the vast amount of biological data residing in the databases. Large amount of data on ARD associated variants, genes and proteins are contained in these databases but they lack connectivity which otherwise is important to decipher the biology of aging and associated diseases. Recently, studies have demonstrated that network approaches helps when applied to integrate biological information can provide novel insights and pave the way for understanding and curing complex diseases. Here we, therefore, propose a new platform ARDInteract that integrate different data sources and allow the creation of heterogeneous networks at various ‘-omic’ levels - SNP, gene, protein, disease and drug interaction levels. ARDInteract provides a user-friendly interface to integrate, visualize and analyse genome-scale biological networks for ARDs ultimately allowing the research community to connect distinct spots in space to solve the puzzle of human aging and ARDs. We believe that by using holistic approach we can achieve our rationale of personalized medicine, and eventually healthy ageing.