IN SILICO ANALYSIS OF BIOMOLECULES FOR LRK2 GENE AND ITS CLINICAL RELEVANCE

Abstract

Millions of individuals worldwide are suffering from Parkinson‘s disease (PD) which is one of the most common neurodegenerative diseases. Clinically characterization of PD can be shown by rigidity, slow movement, rest tremor etc. On gradual progression of the disease, non-motor symptoms such as anxiety, dementia, constipation and depression can be observed. Mutations in these proteins like Parkin, α-synuclein, Leucine-Rich Repeat Kinase 2(LRRK2), PTEN-Induced Kinase (PINK1) can result in development of PD. Lewy bodies [LB] which is one of the major features of PD consists mainly of aggregates of α-synuclein. Numerous inhibitors of LRRK2 kinase are being identified, which can show protective behavior against LRRK2-induced degeneration of neurons. Thus LRRK2 kinase inhibition seems to be a potential new therapeutic agent for the treatment of PD. Natural plants and their derivatives are being utilized as an effective medication for treatment of various disorders since years as they possess many important biological activities such as anti-inflammatory, anti-oxidative, anti-cholinesterase. Desmodium gangeticum, Aloe vera, Ocimum sanctum, Moringa oliefera, Inonotus obliquus plants are being utilized as natural drugs for treatment of PD but their mechanism of action is yet not very clear. In this study we are going to study the interactions of these plants active constituents with LRRK2 kinase protein with the help of protein ligand docking. Therefore, the present study is an attempt for better understanding of the mechanism of action of these plants active constituents as well as comparative study of their effects in the treatment of PD.