EXPLORING THE ROLE OF FTSA FRAGMENT AS A POTENT ANTIMICROBIAL PEPTIDE

Abstract

The quick increase in drug-resistant infections has dispense a significant challenge to antimicrobial therapies. The collapse of the most potent antibiotics to eliminate “superbugs” emphasizes the critical need to develop other control agents. All organism like bacteria, insect, plant and human being produce antimicrobial peptides (AMPs) as vital part of their nonspecific and immediately effective immunity against infection. Antimicrobial peptides are a key component of the innate defense of all species of life. Antimicrobial peptide has different characteristic like antiendotoxic, antibacterial, antibiotic-potentiating or antifungal properties, so they can be utilizing to develop a novel class of antimicrobial agents. Moreover, their capability to destroy microbes, these peptides appear to have effective role in innate immunity and can modulate the expression of multiple genes in eukaryotic cells. Due to their broad spectrum of targeted microbes, AMPs have attracted increasing attention. With the increasing progress of antibiotic resistance between bacterial pathogens, there is a serious requirement to recognize or discover novel classes of antimicrobial peptide.