STUDY OF PROTEIN INTERACTION IN APOPTOTIC PATHWAY IN DIABETES

Abstract

Diabetes is the common non-communicable disease. At the molecular level, pancreatic β cell decreased due to insulin resistance, disturbance in Glut-receptors and excessive accumulation of sugar in the blood. These molecular events trigger the apoptotic pathway that plays a major role in the development of insulin deficiency and the progression of the disease. Proteins that are included in the Bcl-2 family and caspase family are the major regulators of programmed cell death. The proteins interacted with Bcl-2 and caspase also has the important role in this process. The study of different kinds of physiochemical parameters of these proteins is helpful to understand the apoptotic pathway. As Bcl-2 is a major regulator of this process, the Bcl-2 inhibitors are promising drugs for diabetes. In-silico screening of compounds from free databases (ZINC and KEGG) of more than 2 million structures is carried to find out the potential inhibitors.